Computing the Dynamic Supramolecular Structural Proteome
نویسندگان
چکیده
منابع مشابه
Computing the Dynamic Supramolecular Structural Proteome
1 Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America, 2 Sackler Institute of Molecular Medicine, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, 3 University of Virginia, Charlottesvill...
متن کاملStructural bioinformatics of the human spliceosomal proteome
In this work, we describe the results of a comprehensive structural bioinformatics analysis of the spliceosomal proteome. We used fold recognition analysis to complement prior data on the ordered domains of 252 human splicing proteins. Examples of newly identified domains include a PWI domain in the U5 snRNP protein 200K (hBrr2, residues 258-338), while examples of previously known domains with...
متن کاملUnlocking the eukaryotic membrane protein structural proteome.
Most of the 231 unique membrane protein structures (as of 3/2010) are of bacterial membrane proteins (MPs) expressed in bacteria, or eukaryotic MPs from natural sources. However eukaryotic membrane proteins, especially those with more than three membrane crossings rarely succumb to any suitable expression in bacterial cells. They typically require expression in eukaryotic cells that can provide...
متن کاملThe Dynamic Proteome of the Nucleolus
The primary function of the nucleolus is as the site of ribosome subunit biogenesis in eukaryotic cells. Nucleoli reassemble at the end of mitosis around the tandemly repeated clusters of rDNA genes forming a subnuclear compartment that locally concentrates the dedicated transcription and processing machineries that are responsible for generating ribosome subunits. The process of assembling a r...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLOS Computational Biology
سال: 2017
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1005290